Clicker can be used to change Isaac into a more powerful character such as Azazel or The Forgotten, allowing the player to clear rooms more quickly.In the same vein, Plan C is also useful, though only against the final boss. The Bible can be used to instantly kill Mom and It Lives, making it a more valuable item in this run.The invincibility from it can also block timed damage occasionally. Since Isaac starts with increased speed, Taurus can be used to start every room with the My Little Unicorn effect making it effective for clearing rooms quickly.The Ludovico Technique shouldn't be picked up without high shot speed, as it will move slower than most enemies.Stop Watch no longer requires the player to take damage in order to activate the slowing effect.Getting the Stop Watch will make this challenge easier, since it will slow all enemies in the room when Isaac takes damage, counteracting their increased speed.
Certain cards and runes, such as V - The Hierophant, VI - The Lovers, VII - The Chariot, XIX - The Sun, Rune of Algiz, and Rune of Dagaz, can also act as health regeneration or protection to counteract the timed damage or the increased difficulty in general.
Blank Card is a powerful item in this run, as there are cards and runes such as IV - The Emperor, XIX - The Sun, Rune of Ansuz, and Rune of Ehwaz, all of which can enable faster progression through the game.Items that generates health or protection thus help greatly, These include The Wafer, Cancer, Yum Heart, Unicorn Stump, Prayer Card, and many many more. Not only will health compensate for the damage taken, be it from the more difficult rooms/bosses or the timed damage, but it can also be used for Devil Deals to access its high DPS item pool. Health is always important, but even more so in this challenge.Note that the time limit is not a "hard" one and that the game is not over when the countdown timer reaches 0 however, from that point onwards Isaac will start taking half a heart of damage every 10 seconds, or a full heart of damage starting from chapter 4. More importantly, the 16-minute soft time limit is also very hard to beat and may force the player to forgo exploring for rewards that might have helped them later on. Firstly, the increased speed for both the enemies and Isaac can make most routine rooms and bosses challenging. This is arguably one of the hardest challenges in the game, for two major reasons.
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